Marcel Kool Selected Research

Histones (Histone)

1/2022	EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma.
11/2019	EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.
11/2017	Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome.
1/2016	Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity.
5/2013	Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas.
3/2013	OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels.
3/2013	Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.
9/2012	K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas.
1/2012	Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.

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Marcel Kool Research Topics

Disease

127	Neoplasms (Cancer) 12/2023 - 08/2008
91	Medulloblastoma 10/2023 - 02/2006
20	Brain Neoplasms (Brain Tumor) 01/2023 - 11/2010
17	Ependymoma 01/2022 - 12/2011
13	Glioma (Gliomas) 01/2022 - 12/2011
11	Rhabdoid Tumor (Rhabdoid Tumors) 01/2022 - 06/2013
10	Glioblastoma (Glioblastoma Multiforme) 12/2021 - 01/2012
9	Carcinogenesis 01/2023 - 12/2012
8	Primitive Neuroectodermal Tumors (PNET) 01/2021 - 11/2010
6	Typical Teratoid Rhabdoid Tumor 01/2022 - 12/2012
6	Disease Progression 12/2021 - 05/2013
6	Astrocytoma (Pilocytic Astrocytoma) 01/2020 - 08/2013
6	Neoplasm Metastasis (Metastasis) 01/2019 - 04/2012
5	Genomic Instability 10/2023 - 06/2016
4	Neuroblastoma 04/2023 - 07/2013
4	Chromothripsis 01/2022 - 08/2012
2	Osteosarcoma (Osteogenic Sarcoma) 04/2023 - 01/2022
2	Central Nervous System Neoplasms 01/2022 - 01/2022
2	Neuroepithelial Neoplasms (Gliomatosis Cerebri) 01/2020 - 01/2016
2	Isochromosomes 06/2019 - 12/2012
2	Intellectual Disability (Idiocy) 11/2012 - 01/2012
2	Chromosome Aberrations (Chromosome Abnormalities) 04/2011 - 11/2010
1	Rhabdomyosarcoma 04/2023
1	Ewing Sarcoma (Sarcoma, Ewing) 04/2023
1	Leukemia 01/2023
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2023
1	Li-Fraumeni Syndrome 01/2022
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 01/2022
1	Brain Stem Neoplasms (Brain Stem Tumor) 01/2022
1	Chordoma 12/2021
1	Choroid Plexus Papilloma 12/2021

Drug/Important Bio-Agent (IBA)

31	Proteins (Proteins, Gene)FDA Link 01/2023 - 02/2006
19	Messenger RNA (mRNA)IBA 10/2021 - 02/2006
18	RNA (Ribonucleic Acid)IBA 12/2023 - 08/2012
17	Biomarkers (Surrogate Marker)IBA 04/2023 - 11/2010
15	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 04/2011
13	MicroRNAs (MicroRNA)IBA 12/2021 - 11/2010
12	ChromatinIBA 01/2021 - 01/2012
9	Histones (Histone)IBA 01/2022 - 01/2012
9	Transcription Factors (Transcription Factor)IBA 12/2021 - 10/2010
7	ParaffinIBA 12/2022 - 04/2012
6	Formaldehyde (Formol)FDA Link 12/2022 - 04/2012
6	Phosphotransferases (Kinase)IBA 01/2021 - 01/2010
5	Poly(ADP-ribose) Polymerase InhibitorsIBA 04/2023 - 12/2011
5	NucleotidesIBA 11/2021 - 01/2016
5	Small Interfering RNA (siRNA)IBA 01/2018 - 07/2012
4	Histone Deacetylase InhibitorsIBA 05/2023 - 12/2012
4	Lysine (L-Lysine)FDA Link 01/2022 - 03/2013
4	ProteomeIBA 01/2022 - 10/2018
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2023 - 01/2020
3	Dactinomycin (Actinomycin)FDA LinkGeneric 12/2020 - 09/2016
3	Temozolomide (Temodar)FDA LinkGeneric 01/2020 - 11/2015
3	CateninsIBA 01/2019 - 11/2010
3	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2017 - 06/2013
3	Telomerase (Telomerase Reverse Transcriptase)IBA 09/2017 - 12/2013
2	entinostat (MS 275)IBA 05/2023 - 01/2021
2	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 10/2016
2	Polycomb Repressive Complex 2IBA 01/2022 - 11/2019
2	Carboplatin (JM8)FDA LinkGeneric 01/2022 - 10/2018
2	CarbonIBA 12/2021 - 06/2019
2	Arsenic Trioxide (Trisenox)FDA Link 01/2021 - 08/2014
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2021 - 07/2013
2	Methotrexate (Mexate)FDA LinkGeneric 01/2020 - 11/2017
2	Co-Repressor ProteinsIBA 01/2020 - 01/2020
2	HhAntag691IBA 01/2020 - 01/2019
2	Enhancer of Zeste Homolog 2 ProteinIBA 11/2019 - 03/2015
2	Cytostatic AgentsIBA 01/2019 - 10/2016
2	Carrier Proteins (Binding Protein)IBA 01/2017 - 10/2014
2	LigandsIBA 04/2015 - 01/2015
2	Antineoplastic Agents (Antineoplastics)IBA 03/2015 - 07/2014
2	Cytotoxins (Cytolysins)IBA 07/2013 - 12/2011
2	Otx Transcription FactorsIBA 03/2013 - 07/2012
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2023
1	Adenosine Triphosphate (ATP)IBA 05/2023
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2023
1	Immune Checkpoint InhibitorsIBA 01/2023
1	Intergenic DNA (Junk DNA)IBA 01/2023
1	Mitochondrial DNA (mtDNA)IBA 01/2023
1	Chimeric Antigen ReceptorsIBA 01/2023
1	abacavir (Ziagen)FDA Link 03/2022
1	Decitabine FDA Link 03/2022
1	sonidegibIBA 01/2022
1	Etoposide (VP 16)FDA LinkGeneric 01/2022
1	Dyneins (Dynein)IBA 01/2022
1	Long Noncoding RNAIBA 01/2022
1	NivolumabIBA 12/2021
1	Brachyury protein (Brachyury)IBA 12/2021
1	IonsIBA 12/2021

Therapy/Procedure

51	Therapeutics 01/2023 - 11/2010
22	Drug Therapy (Chemotherapy) 01/2023 - 08/2012
10	Radiotherapy 03/2022 - 12/2011
4	Immunotherapy 01/2023 - 12/2016
3	Craniospinal Irradiation 01/2020 - 01/2016
2	Aftercare (After-Treatment) 01/2023 - 01/2022
2	Transcutaneous Electric Nerve Stimulation (TENS) 01/2022 - 06/2016
2	Transplantation 01/2019 - 12/2012
2	Investigational Therapies (Experimental Therapy) 01/2019 - 01/2016
1	Ventriculoperitoneal Shunt 10/2023
1	Combined Modality Therapy 03/2022
1	Heavy Ion Radiotherapy 12/2021